Louise is a census-designated place in Wharton County, Texas, United States. The population was 995 as of the 2010 census.Louise is located at 29�6?42?N 96�24?37?W? / ?29.11167�N 96.41028�W? / 29.11167; -96.41028.According to the United States Census Bureau, the CDP has a total area of 6.6�square miles, all land.Louise is served by the Louise Independent School District.